Macedonian Journal of Medical Sciences
[International, Peer Reviewed]

 

About MJMS

Our policies

MJMS Online

For contributors

Services

Why publish in MJMS?
Editors
Boards
Indexing
Membership 

Editorial & publishing policies
Competing interests policy 
Open access
Open access license

Reviewer guidelines

Online first
Current issue
Journal archive

Online first fact sheet
Free Registration

Guidelines  [pdf]
Online submission
Help for authors
Reviewers of MJMS

Contact

Transliteration
Subscriptions

Advertising
Reprints and permissions
Resources

 

Abstract                                                                         [Full-Text PDF] [Macedonian Abstract] [OnlineFirst Full-Text PDF]

 

Macedonian Journal of Medical Sciences. 2008 Sep 15; 1(1):34-40.

doi:10.3339/MJMS.1857-5773.2008.0006

Clinical Science

 

Chronic Graft-Versus Host Disease - Single Center Experience
 

Zlate Stojanoski1, Aleksandra Pivkova1, Svetlana Krstevska-Balkanov1, Rubens Jovanovik2, Georgi Gocev3, Sonja Genadieva-Stavrik, Lidija Cevreska1, Borche Georgievski1

1Hematology Clinic; 2Institute for Pathology; 3Dermatology Clinic; Medical Faculty, University "Ss Kiril and Metodij", Skopje, Republic of Macedonia

 

Background. With the increasing number of patients surviving peritransplant complications of stem-cell transplantation (SCT), the incidence of chronic Graft Versus Host Disease (cGVHD) has increased too. cGVHD now develops in approximately 30-50% of patients undergoing SCT. Risk factors associated with the development of cGVHD are: previous acuteGVHD (aGVHD), prior cytomegalovirus infection, use of a matched unrelated donor and combination of a male recipient with a female donor. Not all patients who develop aGVHD progress to cGVHD. The latter may occur de novo.

Aim. To describe clinical and patohistological findings and influence of cGVHD on survival in allogeneic stem cell recipients.

Material and methods. During 7 years period we have treated 40 patients with allogeneic SCT from HLA identical sibling. aGVHD prophylaxis comprised Seattle protocol.

Results. 12 patients (6 males, 6 females; mean age: 34,5) developed cGVHD (7 de novo). Distribution according to diagnosis: Acute Myeloid Leukemia (n=8), Chronic Myeloid Leukemia (n=3), Primary myelofibrosis (n=1). Six of them had limited disease, and 6 had extensive. Treatment comprised: corticosteroids + CsA (6), Mophetyl mycophenolate (4), Tacrolimus (2), Photochemiotherapy (3). 10 (83%) patients are alive; 2 (17%) died.

Conclusion. Despite advances in histocompatibility matching and immunosuppressive drugs, GVHD has continued to be a common and often lethal complication of SCT.

 

Key words: Allogeneic stem cell transplantation; graft versus host disease.

 


Publication of the MJMS is supported by the Macedonian Ministry of Education and Sciences.
Publisher:
Institute of Immunobiology and Human GeneticsSkopje, Republic of Macedonia.
This journal is a member of and subscribes to the principles of the Committee on Publication Ethics.
MJMS Print (ISSN 1857-5749) is an international peer-reviewed, Open Access journal published four times per year.
MJMS Online (ISSN 1857-5773) offers free access to all articles at http://www.mjms.ukim.edu.mk/.

Creative Commons Attribution LicenseAll site content, except where otherwise noted, is licensed under a Creative Commons Attribution License.